text / Guan Yanqing/ Yuan Yue
[Sohu Health] Why do some people reduceFat is very difficult, because the mouth is too lonely! This is really not an excuse. Recently, an article published in the "Science" magazine explained the phenomenon that some people "the more fat they love to eat". Mice experiments have shown that after regular consumption of high-fat foods, neurons in the brain that inhibit eating will become "sluggish", leading to more calories.
Many fat people have this experience. The more high-fat foods they eat, the more they can’t stop talking. In order to explore the reasons behind this phenomenon, researchers at the University of North Carolina in the United States established a mouse model of a high-fat diet.
In this study, researchers cut a small hole in the skull of mice and blocked them with tiny “windows” to use special A microscope to observe neurons in a living brain. Later, they fed these mice high-fat foods and watched them slowly get fat.
The neuron that the researchers focused on was the glutamatergic neuron (LHA Vglut2) in the mouse brain. According to previous studies, the lower side of the brainThe LHA Vglut2 in the thalamus is involved in regulating hunger and can tell the mice when to eat enough. When LHA Vglut2 is inhibited, the mice become overeating and uncontrollable.
The observation results show that only two weeks after the implementation of the high-fat diet, the LHA Vglut2 in the brain of the mice began to become less active. Until the 12th week, the activity of LHA Vglut2 continued to decline. However, the activity of LHA Vglut2 neurons did not change in the control mice that had been eating ordinary rat food.
Humans are fundamentally different, but the researchers pointed out that previous studies have shown that the human hypothalamus is involved in regulating hunger. That is, it is likely that the same types of neurons in the human brain also function in the same way.
The University of Aberdeen neuroscientist Lora Heisler said, This study shows that regular consumption of sweets and high-fat foods "will change the appetite center function of the brain. Because the brain’s response to sweets is weakened, it means that we Will eat more than needed".
Except thatIn addition, another study also confirmed that high-sugar and high-fat foods make people unable to stop. Thomas Kash, professor of pharmacology at the University of North Carolina, found that both humans and mice like high-sugar and high-fat foods. In the process of eating sweets, a protein called nioceptin is very active in the body, prompting the body to take in more of these foods.
In other words, "the fatter you are, the more you love to eat" is not completely unreasonable. Without tenacious willpower, it is really difficult to lose weight.
Obesity remodels activity and tranional state of a lateral hypothalamic brakeon feeding
2. Medical Xpress
Brain cells that curb overeating found diminished activity in mice on a high-fat diet